Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654035 | 0.91 | HPGD (0.38) | HPGDALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2654086 | 0.84 | GCGR (0.40) | HPGDMAPTSMN1; SMN2LMNAEPHX2 | |
| SCHEMBL2654877 | 0.82 | HPGD (0.36) | HPGDMAPTSMN1; SMN2LMNAADRB2 | |
| SCHEMBL2653842 | 0.82 | ALDH1A1 (0.38) | HPGDALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL2653014 | 0.81 | SMN1; SMN2 (0.36) | HPGDMAPTSMN1; SMN2LMNANAMPT | |
| SCHEMBL2654239 | 0.81 | GCGR (0.41) | MAPTLMNA | |
| SCHEMBL2655747 | 0.80 | MCL1 (0.40) | POLBSMN1; SMN2NPC1EPHX2 | |
| SCHEMBL2653999 | 0.79 | FFAR1 (0.41) | SMN1; SMN2NPC1EPHX2 | |
| SCHEMBL2654772 | 0.79 | GCGR (0.36) | — | |
| SCHEMBL2652978 | 0.78 | ALDH1A1 (0.41) | HPGDALDH1A1POLBSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |