Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 7/20 | 0.67 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.67 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.67 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.66 |
| ▸ | TSHR | P16473 | 9/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.64 |
| ▸ | USP2 | O75604 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652423 | 0.84 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA3CYP1A2 | |
| SCHEMBL2652170 | 0.81 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3CYP1A2 | |
| SCHEMBL34462886 | 0.76 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2C19CLK4TSHR | |
| SCHEMBL2652039 | 0.72 | GABRG2 (0.68) | GABRG2GABRB3GABRA5GABRA3CLK4 | |
| SCHEMBL27839928 | 0.71 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2C19CLK4TSHR | |
| SCHEMBL3273762 | 0.71 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2C19CLK4TSHR | |
| SCHEMBL27709761 | 0.70 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2C19CLK4TSHR | |
| SCHEMBL3304650 | 0.68 | ADORA2A (0.73) | CYP1A2CYP3A4CYP2C19CLK4TSHR | |
| SCHEMBL2655128 | 0.68 | GABRG2 (0.73) | GABRG2GABRB3GABRA5GABRA3TSHR | |
| SCHEMBL2652644 | 0.67 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235021-A1 | Phenylpyridazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2006-10-19 | — | — | US | claimed |
| EP-1532120-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-25 | — | — | EP | claimed |
| WO-2004014865-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-19 | — | — | WO | claimed |
| US-20060235021-A1 | Phenylpyridazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2006-10-19 | — | — | US | disclosed |
| EP-1532120-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004014865-A1 | PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235021-A1 | Phenylpyridazine derivatives as ligands for gaba receptors | GABRA5, GABRA2, GABRA3 | GABRG2 20/4885GABRB3 8/4885GABRA5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.