Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | AQP1 | P29972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10489857 | 0.82 | METAP2 (0.59) | METAP2KDM4EFAAH | |
| SCHEMBL28746968 | 0.81 | CA12 (0.48) | METAP2CA2ALDH1A1HPGDFAAH | |
| SCHEMBL30361520 | 0.79 | FAAH (0.52) | FAAHRAB9A | |
| SCHEMBL28261566 | 0.79 | FAAH (0.49) | FAAHRAB9A | |
| SCHEMBL28698992 | 0.77 | CA1 (0.56) | CA2CA1CA12CA9 | |
| SCHEMBL10112975 | 0.76 | FAAH (0.67) | KDM4EALDH1A1LMNAHPGDFAAH | |
| SCHEMBL10489769 | 0.75 | METAP2 (0.57) | METAP2KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL9126282 | 0.74 | FAAH (0.44) | FAAHRAB9A | |
| SCHEMBL29233073 | 0.74 | RAB9A (0.74) | ALDH1A1LMNAHPGDFAAHRAB9A | |
| SCHEMBL7339580 | 0.72 | FAAH (0.72) | KDM4EALDH1A1LMNAHPGDFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183229-B1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK AS (DK) | 2005-10-26 | — | — | EP | disclosed |
| US-6503949-B1 | Treating Type 2 diabetes, hyperglycemia, impaired glucose tolerance or obesity | NORO NORDISK A/S (DK) | 2003-01-07 | — | — | US | disclosed |
| EP-1183229-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069810-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-11-23 | — | — | WO | disclosed |