Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655083 | 0.87 | HPGD (0.38) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2654673 | 0.79 | FGFR1 (0.53) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2654510 | 0.79 | GABRA1 (0.40) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2653488 | 0.78 | FGFR1 (0.38) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2654425 | 0.78 | GABRA1 (0.54) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2645149 | 0.77 | HTT (0.39) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2643019 | 0.77 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2665437 | 0.77 | GABRA1 (0.41) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL2654024 | 0.77 | FGFR1 (0.62) | HPGDGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8232331 | 0.77 | MEN1 (0.43) | HPGDFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335777-B2 | Benzimidazole derivatives and their use for modulating the GABAA receptor complex | NEUROSEARCH A/S (DK) | 2008-02-26 | — | — | US | claimed |
| EP-1613312-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA A RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2008-02-20 | — | — | EP | claimed |
| US-20060148856-A1 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex | ANIONA APS (DK) | 2006-07-06 | — | — | US | claimed |
| EP-1613312-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA sb A /sb RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-01-11 | — | — | EP | claimed |
| WO-2004087137-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2004-10-14 | — | — | WO | claimed |
| US-7335777-B2 | Benzimidazole derivatives and their use for modulating the GABAA receptor complex | NEUROSEARCH A/S (DK) | 2008-02-26 | — | — | US | disclosed |
| EP-1613312-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA A RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2008-02-20 | — | — | EP | disclosed |
| US-20060148856-A1 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex | ANIONA APS (DK) | 2006-07-06 | — | — | US | disclosed |
| EP-1613312-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA sb A /sb RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087137-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2004-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148856-A1 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex | GABRB2, GABRB1, GABRB3 | HPGD 1505/4885GABRA1 5/4885GABRG2 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.