Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 4/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248501 | 0.76 | KDR (1.00) | KDRCHEK1GSK3BFLT3 | |
| SCHEMBL5251631 | 0.76 | KDR (1.00) | KDRCHEK1GSK3BFLT3 | |
| SCHEMBL2650330 | 0.76 | FLT3 (0.74) | KDRCHEK1GSK3BFLT3MAP4K4 | |
| SCHEMBL111003 | 0.75 | KDR (0.60) | KDRCHEK1GSK3BFYNFLT3 | |
| SCHEMBL15757581 | 0.75 | FLT3 (0.68) | KDRCHEK1GSK3BFYNFLT3 | |
| SCHEMBL18237574 | 0.73 | CYP11B1 (0.37) | KDRCHEK1GSK3B | |
| SCHEMBL15287989 | 0.73 | KDR (0.57) | KDRCHEK1GSK3BFYNFLT3 | |
| SCHEMBL5251591 | 0.71 | KDR (1.00) | KDRFLT3 | |
| SCHEMBL15756965 | 0.71 | MAP3K14 (0.54) | KDRCHEK1GSK3BFYNFLT3 | |
| SCHEMBL30217979 | 0.70 | CHEK1 (0.51) | KDRCHEK1GSK3BFYNFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6914065-B2 | Imidazo[1,2-C]pyrimidine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. | 2005-07-05 | — | — | US | disclosed |
| US-20040138236-A1 | Imidazo-pyrimidine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2004-07-15 | — | — | US | disclosed |
| WO-2002038569-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138236-A1 | Imidazo-pyrimidine derivatives as ligands for gaba receptors | GABRA3, GABRA2, GABRA1 | KDR 910/4885CHEK1 1223/4885GSK3B 1729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.