Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | MMP16 | P51512 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28565924 | 0.98 | PTGDR2 (0.47) | PTGDR2PTGS2PTGS1PTGDRCXCL8 | |
| SCHEMBL21784784 | 0.93 | MMP2 (0.42) | PTGDR2PTGS2PTGS1CXCL8MMP1 | |
| SCHEMBL10810341 | 0.85 | CXCL8 (0.38) | PTGS2PTGS1CXCL8MMP1MMP2 | |
| SCHEMBL4618238 | 0.84 | PTGDR2 (0.41) | PTGDR2PTGS2PTGS1PTGDRCXCL8 | |
| SCHEMBL415803 | 0.81 | PTGDR2 (0.45) | PTGDR2PTGS2PTGS1PTGDRLMNA | |
| SCHEMBL2062948 | 0.81 | PTGDR2 (0.45) | PTGDR2PTGS2PTGS1PTGDRLMNA | |
| SCHEMBL418663 | 0.81 | PTGDR2 (0.45) | PTGDR2PTGS2PTGS1PTGDRLMNA | |
| Hydrogen Peroxide SCHEMBL11527811 | 0.81 | PTGDR2 (0.44) | PTGDR2PTGS2PTGS1PTGDREPHX1 | |
| Vedaprofen SCHEMBL29539506 | 0.80 | PTGS1 (0.41) | PTGDR2PTGS2PTGS1PTGDRCXCL8 | |
| Vedaprofen SCHEMBL505781 | 0.80 | PTGS1 (0.41) | PTGDR2PTGS2PTGS1PTGDRCXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934233-A1 | SULFONAMIDE DERIVATIVES AS GLYCOKINASE ACTIVATORS USEFUL IN THE TREATMENT OF TYPE 2 DIABETES | Novartis AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007041366-A1 | SULFONAMIDE DERIVATIVES AS GLYCOKINASE ACTIVATORS USEFUL IN THE TREATMENT OF TYPE 2 DIABETES | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | disclosed |