Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | MMP16 | P51512 | 2/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | GLP1R | P43220 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653447 | 0.93 | PTGDR2 (0.44) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL28565924 | 0.92 | PTGDR2 (0.47) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL10810341 | 0.82 | CXCL8 (0.38) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL3673539 | 0.81 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CGBA1SLC6A2 | |
| SCHEMBL27614694 | 0.79 | GPR119 (0.53) | MAPTSMN1; SMN2KDM4EALDH1A1MAPK1 | |
| SCHEMBL28068538 | 0.79 | PTGDR2 (0.36) | ADRA2AADRA2BADRA2CGBA1HSD17B10 | |
| SCHEMBL2204495 | 0.78 | PTGS2 (0.56) | MMP2MMP9MMP8MMP12MMP13 | |
| SCHEMBL4618238 | 0.78 | PTGDR2 (0.41) | CXCL8PTGS2PTGS1GLP1RMAPT | |
| SCHEMBL18448149 | 0.77 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CPTGS1GBA1 | |
| SCHEMBL27565324 | 0.77 | HTR2C (0.51) | ADRA2AADRA2BADRA2CSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047239-A1 | INHIBITING αV β6 INTEGRIN | MORPHIC THERAPEUTIC, INC. (US) | 2020-03-05 | — | — | WO | disclosed |