Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5674929 | 1.00 | EPHX1 (0.53) | EPHX1AKR1C3AKR1C2ENPP2CA12 | |
| SCHEMBL38657609 | 0.85 | CA2 (0.55) | EPHX1CA12CA1CA2CA4 | |
| SCHEMBL27536782 | 0.84 | AKR1C3 (0.53) | AKR1C3AKR1C2ENPP2LMNATSHR | |
| SCHEMBL13723847 | 0.82 | AKR1C3 (0.70) | AKR1C3AKR1C2ENPP2GRM4LMNA | |
| SCHEMBL28202578 | 0.82 | AKR1C3 (0.56) | AKR1C3AKR1C2ENPP2LMNATSHR | |
| SCHEMBL22643594 | 0.81 | AKR1C3 (0.44) | EPHX1AKR1C3AKR1C2ENPP2GRM4 | |
| SCHEMBL27705668 | 0.81 | HTR6 (0.50) | EPHX1LMNA | |
| SCHEMBL16879899 | 0.81 | EPHX1 (0.54) | EPHX1AKR1C3AKR1C2CA12CA1 | |
| SCHEMBL30838569 | 0.80 | AKR1C3 (0.46) | AKR1C3AKR1C2ENPP2CA12CA1 | |
| SCHEMBL7289374 | 0.79 | LMNA (0.47) | EPHX1AKR1C3AKR1C2ENPP2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341774-B1 | FUSED HETEROAROMATIC GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2006-02-01 | — | — | EP | claimed |
| EP-1572670-A1 | 5-SUBSTITUTED-PYRAZINE OR -PYRIDINE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-14 | — | — | EP | claimed |
| WO-2004052869-A1 | 5-SUBSTITUTED-PYRAZINE OR PYRIDINE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-24 | — | — | WO | claimed |
| CN-112851557-B | Sulfo-substituted biaryl compound or salt thereof, and preparation method and application thereof | 上海辉启生物医药科技有限公司 | 2022-06-10 | — | — | CN | disclosed |
| CN-1226294-C | Fused heteroaromatic glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-11-09 | — | — | CN | disclosed |
| EP-1572670-A1 | 5-SUBSTITUTED-PYRAZINE OR -PYRIDINE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004052869-A1 | 5-SUBSTITUTED-PYRAZINE OR PYRIDINE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-24 | — | — | WO | disclosed |
| CN-1476438-A | Fused heteroaromatic glucokinase activators | - | 2004-02-18 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |