Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Permethrin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Permethrin SCHEMBL29397229 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL29442911 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL9665188 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL9669087 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL117908 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL910678 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL24089572 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL9754130 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL121233 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL584812 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 53883 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4289275-B1 | INSECT REPELLENT COMPOSITION | UNIV WIEN BODENKULTUR (AT) | 2026-05-27 | — | — | EP | claimed |
| US-20260137082-A1 | FUNGICIDAL COMPOSITIONS COMPRISING FLUDIOXONIL | SYNGENTA CROP PROTECTION AG (CH) | 2026-05-21 | — | — | US | claimed |
| US-20260137087-A1 | INSECTICIDAL COMPOSITIONS RESISTANT TO ACTIVE INGREDIENT DEGRADATION AND PROCESS FOR PREPARATION THEREOF | UPL LTD (IN) | 2026-05-21 | — | — | US | claimed |
| EP-4742903-A1 | AGROCHEMICAL COMBINATIONS, COMPOSITIONS AND METHOD OF USE THEREOF | UPL Mauritius Limited (MU) | 2026-05-20 | — | — | EP | claimed |
| CN-122030420-A | Sustained-release liquid preparation insecticidal aerosol and preparation method thereof | 肇庆市奥帝精细化工有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122011556-A | Anti-mosquito fabric base material resin and preparation method and application thereof | 上海纤智新材料科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4734762-A1 | BAIT COMPOSITIONS | FMC Corporation (US) | 2026-05-06 | — | — | EP | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| WO-2026085578-A1 | RESIDUAL INSECTICIDE COMPOSITION AND USE THEREOF | CALLINGTON HAVEN PTY LTD (AU) | 2026-04-30 | — | — | WO | claimed |
| WO-2026085577-A1 | INSECTICIDE COMPOSITION AND USE THEREOF | CALLINGTON HAVEN PTY LTD (AU) | 2026-04-30 | — | — | WO | claimed |
| EP-0008207-A2 | Insecticidal compositions, and preparation and use thereof | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-02-20 | — | — | EP | claimed |
| EP-0006212-A1 | System of pulverisation in the form of an aerosol | Airwick AG (CH) | 1980-01-09 | — | — | EP | claimed |
| EP-0005826-A1 | Synergistic pyrethroid formulations and their preparation | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-12-12 | — | — | EP | claimed |
| US-4178384-A | A 3-DICHLOROVINYL-2,2-DIMETHYL CYCLOPROPANE CARBOXYLATE | FMC CORPORATION (US) | 1979-12-11 | — | — | US | claimed |
| EP-0003251-A1 | Insecticidal formulations and process for their preparation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-08-08 | — | — | EP | claimed |
| US-4152454-A | Insecticidal compositions comprising N'-aryl-N-methylformamidines and 3-phenoxybenzyl carboxylates | FMC CORPORATION (US) | 1979-05-01 | — | — | US | claimed |
| EP-0001454-A1 | Arthropodicidal compositions, formulations containing such compositions and the use of such compositions or formulations in controlling pests | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-04-18 | — | — | EP | claimed |
| US-4144331-A | Synergistic chlorfenvinphos and pyrethroid pesticidal composition | SHELL OIL COMPANY (US) | 1979-03-13 | — | — | US | claimed |
| US-3969393-A | Process for preparing cyclopropane-carboxylic acid esters | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-07-13 | — | — | US | claimed |
| US-3944666-A | Insecticidal compositions and methods of combatting insects using 3-phenoxybenzyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropanecarboxylate insecticide with a synergistic compound of mono (alkyl and alkenyl)mono omega-alkynyl arylphosphonates | FMC CORPORATION (US) | 1976-03-16 | — | — | US | claimed |