Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Permethrin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Permethrin SCHEMBL29397229 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL29442911 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL9665188 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL9669087 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL117908 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL910678 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL24089572 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL26543 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL121233 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM | |
| Permethrin SCHEMBL584812 | 1.00 | TDP1 (1.00) | TDP1LMNAADRA2ACNR1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3506748-A1 | IMPROVED METHOD FOR THE SYNTHESIS OF PERMETHRIN | Biophore India Pharmaceuticals Pvt. Ltd. (IN) | 2019-07-10 | — | — | EP | disclosed |
| WO-1991019038-A1 | A METHOD FOR INSECT-RESIST TREATMENT OF CARPET AND TEXTILES | LAPPAGE, JAMES (NZ) | 1991-12-12 | — | — | WO | disclosed |