Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654694 | 0.93 | CYP4A11 (0.47) | CCR6HKDC1CYP4A11CYP4F2MAPT | |
| SCHEMBL2655395 | 0.81 | GCGR (0.41) | CYP4A11MAPTLMNATP53MEN1 | |
| SCHEMBL2655622 | 0.77 | ALDH1A1 (0.45) | CCR6HKDC1CYP4A11CYP4F2MAPT | |
| SCHEMBL2652782 | 0.74 | CYP4A11 (0.61) | CCR6HKDC1CYP4A11CYP4F2MAPT | |
| SCHEMBL2654520 | 0.74 | LMNA (0.49) | CCR6HKDC1CYP4A11MAPTALDH1A1 | |
| SCHEMBL17386082 | 0.73 | CCR6 (0.56) | CCR6HKDC1CYP4A11CYP4F2MAPT | |
| SCHEMBL19002551 | 0.72 | CYP4A11 (0.62) | CCR6HKDC1CYP4A11CYP4F2MAPT | |
| SCHEMBL19922221 | 0.71 | CYP4A11 (0.60) | CCR6HKDC1CYP4A11CYP4F2MAPT | |
| SCHEMBL2654945 | 0.70 | RXRA (0.38) | CYP4A11CYP4F2TP53RAB9AMEN1 | |
| SCHEMBL17429666 | 0.70 | CCR6 (0.59) | CCR6HKDC1CYP4A11CYP4F2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957068-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | Eli Lilly & Company (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007120270-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-10-25 | — | — | WO | disclosed |