Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KLK1 | P06870 | 2/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 2/20 | 0.35 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 3/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26543681 | 0.89 | PLG (0.38) | PLGPLAUKMT2AMAPTKLK1 | |
| SCHEMBL24379800 | 0.79 | MEN1 (0.54) | KMT2AMAPTALDH1A1HTTNR1H4 | |
| SCHEMBL20786981 | 0.78 | MITF (0.42) | PLGPLAUKMT2AMAPTALDH1A1 | |
| SCHEMBL20787628 | 0.76 | MEN1 (0.41) | PLAUKMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL30625925 | 0.76 | LMNA (0.47) | KMT2AMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL29500371 | 0.76 | MAPT (0.45) | KMT2AMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL17795120 | 0.76 | MAPT (0.45) | KMT2AMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL19151924 | 0.76 | MAPT (0.45) | KMT2AMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL22099920 | 0.75 | POLB (0.40) | PLGPLAUKMT2AMAPTKLK1 | |
| SCHEMBL26542645 | 0.75 | HDAC1 (0.33) | PLGPLAUKMT2AHTTEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196788-A2 | METAGENOME-GUIDED BIOSYNTHESIS AND COMPOUNDS AND METHODS OF USE THEREOF | THE ROCKEFELLER UNIVERSITY (US) | 2023-10-12 | — | — | WO | disclosed |