Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 7/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26545899 | 0.86 | ILK (0.44) | MAPTALOX12PKMALDH1A1GAA | |
| SCHEMBL26545988 | 0.84 | ALOX12 (0.65) | MAPTALOX12PKMALDH1A1GAA | |
| SCHEMBL26546062 | 0.84 | ALOX12 (0.54) | MAPTALOX12PKMALDH1A1CA12 | |
| SCHEMBL26545984 | 0.84 | ALOX12 (0.65) | MAPTALOX12PKMALDH1A1GAA | |
| SCHEMBL26546076 | 0.84 | PKM (0.49) | MAPTALOX12PKMALDH1A1GAA | |
| SCHEMBL26546033 | 0.82 | ALOX12 (0.67) | ALOX12PKMALDH1A1GAALMNA | |
| SCHEMBL26545834 | 0.82 | GAA (0.71) | MAPTALOX12ALDH1A1GAALMNA | |
| SCHEMBL26545970 | 0.81 | ALOX12 (0.51) | MAPTALOX12PKMALDH1A1GAA | |
| SCHEMBL27821552 | 0.80 | GAA (0.60) | MAPTPKMALDH1A1GAACA12 | |
| SCHEMBL16646129 | 0.77 | ALOX12 (0.74) | MAPTALOX12PKMALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024019959-A1 | COMPOSITIONS FOR MODULATING LIPOXYGENASE AND METHODS OF USING SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-01-25 | — | — | WO | disclosed |
| EP-3054936-B1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2023-10-18 | — | — | EP | disclosed |