Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.45 |
| ▸ | GCGR | P47871 | 14/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | GIPR | P48546 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | GLP1R | P43220 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655431 | 0.92 | EPHX2 (0.47) | GCGRGIPRMLYCD | |
| SCHEMBL2656425 | 0.85 | HRH3 (0.44) | — | |
| SCHEMBL2654485 | 0.84 | NPC1 (0.47) | GCGRGIPR | |
| SCHEMBL2653591 | 0.82 | EPHX2 (0.56) | GCGRGIPRMLYCD | |
| SCHEMBL2654574 | 0.82 | GCG (0.57) | — | |
| SCHEMBL2653397 | 0.82 | HSD17B10 (0.49) | — | |
| SCHEMBL2656017 | 0.82 | S1PR1 (0.53) | GCGRCYSLTR2CYSLTR1 | |
| SCHEMBL2654640 | 0.81 | MEN1 (0.43) | MLYCD | |
| SCHEMBL2655586 | 0.81 | GCGR (0.48) | GCGRGIPR | |
| SCHEMBL2654996 | 0.81 | FFAR1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |