Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 2/20 | 0.33 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26798707 | 0.85 | HCAR3 (0.50) | HCAR3PDE10ADEGS1HCAR2GAA | |
| SCHEMBL13312903 | 0.80 | HCAR3 (0.49) | HCAR3POLBGAAALDH1A1LMNA | |
| SCHEMBL21016713 | 0.79 | HCAR3 (0.47) | HCAR3DEGS1MAP3K5POLBGAA | |
| SCHEMBL247457 | 0.78 | GAA (0.39) | DEGS1MAP3K5POLBGAAALDH1A1 | |
| SCHEMBL21016712 | 0.78 | VNN1 (0.37) | DEGS1MAP3K5POLBGAAALDH1A1 | |
| SCHEMBL23768156 | 0.78 | HCAR3 (0.51) | HCAR3PDE10ADEGS1OGAHCAR2 | |
| SCHEMBL21017113 | 0.75 | HCAR3 (0.51) | HCAR3IRAK4DEGS1MAP3K5POLB | |
| SCHEMBL26550128 | 0.74 | IDH2 (0.40) | HCAR3FDPS | |
| SCHEMBL3723734 | 0.73 | HCAR3 (0.58) | HCAR3PDE10ADEGS1 | |
| SCHEMBL7866663 | 0.72 | HCAR3 (0.53) | HCAR3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |