Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 2/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18924324 | 0.86 | IDH2 (0.41) | IDH2MAPK14MAPK10HRH4FDPS | |
| SCHEMBL17131648 | 0.81 | IDH2 (0.55) | IDH2MAPK14MAPK10ARMAP3K12 | |
| SCHEMBL12714521 | 0.74 | ALDH1A1 (0.38) | IDH2MAPK14MAPK10HRH4FDPS | |
| SCHEMBL26547688 | 0.74 | MAPK14 (0.42) | MAPK14MAPK10HRH4FDPSHCAR3 | |
| SCHEMBL26547631 | 0.74 | HCAR3 (0.51) | FDPSHCAR3 | |
| SCHEMBL14868354 | 0.73 | ADRB2 (0.42) | PROKR1 | |
| SCHEMBL828257 | 0.72 | FDPS (0.59) | MAPK14MAPK10HRH4FDPSTRPM8 | |
| SCHEMBL29851369 | 0.72 | FDPS (0.59) | MAPK14MAPK10HRH4FDPSTRPM8 | |
| SCHEMBL23066110 | 0.71 | MAPK14 (0.47) | MAPK14MAPK10HRH4FDPSPROKR1 | |
| SCHEMBL12356613 | 0.71 | MAPK14 (0.42) | MAPK14MAPK10HRH4FDPSHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |