Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26550293 | 0.81 | HTR7 (0.41) | MAPK14BRAFKDRTNNI3KHTR7 | |
| SCHEMBL26550291 | 0.79 | EGFR (0.39) | MAPK14BRAFKDRTNNI3KKMT2A | |
| SCHEMBL12411077 | 0.78 | NPC1 (0.44) | MAPK14BRAFKDRTNNI3KKMT2A | |
| SCHEMBL5416069 | 0.75 | BRAF (0.35) | MAPK14BRAFKDRTNNI3KKMT2A | |
| SCHEMBL26550285 | 0.73 | MAPK14 (0.41) | MAPK14KDRALDH1A1MAPK10HTR7 | |
| SCHEMBL26038044 | 0.73 | HTR7 (0.36) | MAPK14BRAFKDRTNNI3KKMT2A | |
| SCHEMBL26547875 | 0.70 | HTR7 (0.39) | HTR7 | |
| SCHEMBL7486936 | 0.68 | THRB (0.38) | KMT2ATHRBALDH1A1HTR7 | |
| SCHEMBL7489421 | 0.68 | THRB (0.38) | MAPK14BRAFKDRTNNI3KKMT2A | |
| SCHEMBL12676418 | 0.67 | TRPM8 (0.45) | MAPK14BRAFKDRTNNI3KTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |