Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DNM2 | P50570 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26547875 | 0.88 | HTR7 (0.39) | HTR7HTR6MAPTDNM2P4HTM | |
| SCHEMBL26547873 | 0.81 | MAPK14 (0.38) | HTR7BRAFKDRMAPK14TNNI3K | |
| SCHEMBL7998281 | 0.79 | HTR6 (0.42) | HTR7HTR6MAPTATM | |
| SCHEMBL7999124 | 0.76 | HTR7 (0.41) | HTR7HTR6ATMCHRNB2CHRNA4 | |
| SCHEMBL12411077 | 0.75 | NPC1 (0.44) | MAPTBRAFKDRMAPK14TNNI3K | |
| SCHEMBL26550287 | 0.75 | CHRNB2 (0.44) | HTR7MAPTCHRNB2CHRNA4 | |
| SCHEMBL12820402 | 0.75 | HTR7 (0.40) | HTR7HTR6MAPTATMCHRNB2 | |
| SCHEMBL15114898 | 0.74 | HTR7 (0.47) | HTR7HTR6MAPTP4HTMCHRNB2 | |
| SCHEMBL5416069 | 0.73 | BRAF (0.35) | BRAFKDRMAPK14TNNI3K | |
| SCHEMBL2237291 | 0.72 | HTR7 (0.46) | HTR7HTR6MAPTP4HTMCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |