Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.41 |
| ▸ | KRAS | P01116 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26547881 | 0.84 | MAPK8 (0.47) | MAPK8HRH4SMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL12411107 | 0.82 | HTR7 (0.47) | MAPK8HRH4LMNACCR4HTR7 | |
| SCHEMBL12411165 | 0.82 | MAPK8 (0.49) | MAPK8HRH4MEN1CYP1A2KMT2A | |
| SCHEMBL26550296 | 0.79 | ALDH1A1 (0.40) | SMN1; SMN2TSHRMEN1CYP1A2KMT2A | |
| SCHEMBL2017242 | 0.73 | TSHR (0.39) | SMN1; SMN2TSHRACACB | |
| SCHEMBL8000442 | 0.72 | CHRNB1 (0.49) | — | |
| SCHEMBL12411129 | 0.72 | MAPK8 (0.41) | MAPK8HRH4MEN1CYP1A2KMT2A | |
| SCHEMBL31201109 | 0.71 | NUDT1 (0.59) | HRH4TSHR | |
| SCHEMBL12411162 | 0.69 | MAPK8 (0.47) | MAPK8HRH4SMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL2844731 | 0.69 | ABL1 (0.52) | MAPK8HRH4MEN1KMT2AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |