Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1565789 | 0.86 | LMNA (0.48) | ALDH1A1MEN1NPC1LMNAMAPT | |
| SCHEMBL2654801 | 0.78 | MAPT (0.49) | ALDH1A1MAPTKDM4EPOLBFFAR2 | |
| SCHEMBL1565388 | 0.76 | MEN1 (0.48) | ALDH1A1MEN1NPC1LMNAMAPT | |
| SCHEMBL1565386 | 0.72 | KMT2A (0.42) | ALDH1A1MEN1NPC1LMNAMAPT | |
| SCHEMBL11136753 | 0.72 | EPHX1 (0.59) | ALDH1A1MEN1LMNAMAPTKMT2A | |
| SCHEMBL2653273 | 0.71 | MAPT (0.50) | ALDH1A1MEN1NPC1LMNAMAPT | |
| SCHEMBL6965016 | 0.70 | NPC1 (0.56) | ALDH1A1MEN1NPC1LMNAMAPT | |
| Chlorobenzene SCHEMBL27740260 | 0.70 | FFAR2 (0.51) | ALDH1A1MEN1NPC1LMNAMAPT | |
| SCHEMBL2652656 | 0.69 | KMT2A (0.51) | ALDH1A1MEN1NPC1LMNARAB9A | |
| SCHEMBL1565595 | 0.69 | MAPT (0.47) | ALDH1A1MEN1NPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | disclosed |