Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | GALR1 | P47211 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3086027 | 0.88 | SLC18A3 (0.41) | SMN1; SMN2KMT2ALMNAMAPTSLC18A3 | |
| Trifluoroacetic Acid SCHEMBL23727646 | 0.86 | MAPK1 (0.38) | SMN1; SMN2KMT2ALMNASLC18A3MAPK1 | |
| SCHEMBL26548097 | 0.84 | CYP19A1 (0.37) | KMT2ALMNAMAPTSLC18A3DDB1 | |
| SCHEMBL16680561 | 0.81 | MAPK1 (0.38) | SMN1; SMN2KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL20408764 | 0.81 | MAPT (0.44) | SMN1; SMN2KMT2ALMNAMAPTSLC18A3 | |
| SCHEMBL960888 | 0.80 | L3MBTL1 (0.45) | SMN1; SMN2LMNAMAPTSLC18A3IKBKB | |
| SCHEMBL25301696 | 0.79 | HTR3A (0.38) | SMN1; SMN2KMT2ALMNAMAPTIKBKB | |
| SCHEMBL28945417 | 0.75 | MAPT (0.41) | SMN1; SMN2KMT2AMAPTIKBKBGAA | |
| SCHEMBL30933201 | 0.74 | MAPK1 (0.38) | SMN1; SMN2KMT2ALMNAMAPTMAPK1 | |
| SCHEMBL24757849 | 0.74 | MAPK1 (0.38) | SMN1; SMN2KMT2ALMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | SMN1; SMN2 1161/4885KMT2A 1669/4885LMNA 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.