Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PHF8 | Q9UPP1 | 5/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.43 |
| ▸ | KDM5C | P41229 | 3/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411873 | 0.98 | KDM4E (0.47) | ALDH1A1KDM4ESMN1; SMN2TP53HTT | |
| SCHEMBL16353590 | 0.80 | CA12 (0.50) | ALDH1A1KDM4ESMN1; SMN2TP53HTT | |
| SCHEMBL265358 | 0.80 | GLA (0.48) | ALDH1A1KDM4ESMN1; SMN2TP53HTT | |
| SCHEMBL23375057 | 0.80 | PHF8 (0.43) | ALDH1A1KDM4ESMN1; SMN2TP53PHF8 | |
| SCHEMBL271770 | 0.80 | HTT (0.41) | ALDH1A1KDM4ESMN1; SMN2TP53HTT | |
| SCHEMBL493880 | 0.79 | TP53 (0.50) | ALDH1A1KDM4ESMN1; SMN2TP53HTT | |
| SCHEMBL3878624 | 0.79 | HTT (0.43) | ALDH1A1KDM4ETP53HTTL3MBTL1 | |
| SCHEMBL2364252 | 0.79 | TP53 (0.50) | ALDH1A1KDM4ESMN1; SMN2TP53HTT | |
| SCHEMBL15055257 | 0.79 | HTT (0.43) | ALDH1A1KDM4ESMN1; SMN2TP53HTT | |
| SCHEMBL15055190 | 0.79 | HTT (0.43) | ALDH1A1KDM4ESMN1; SMN2TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133888-B2 | Hydrazide containing taxane conjugates | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| US-20110172226-A1 | NOVEL HYDRAZIDE CONTAINING TAXANE CONJUGATES | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172226-A1 | NOVEL HYDRAZIDE CONTAINING TAXANE CONJUGATES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-3, H1-5 | ALDH1A1 43/4885KDM4E 2897/4885SMN1; SMN2 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.