Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SOD1 | P00441 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654649 | 0.82 | PTGDR2 (0.37) | ALDH1A1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL2652831 | 0.81 | PTGDR2 (0.35) | ALDH1A1MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL2654132 | 0.80 | PTGS2 (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2PTGDR2 | |
| SCHEMBL2655512 | 0.71 | PTGDR2 (0.55) | MEN1KMT2ACYP3A4MAPTRAB9A | |
| SCHEMBL2654413 | 0.66 | PTGDR2 (0.51) | MEN1KMT2ACYP3A4SMN1; SMN2RAB9A | |
| SCHEMBL15912493 | 0.66 | HDAC4 (0.33) | HPGDALDH1A1KMT2ACYP1A2MAPT | |
| SCHEMBL2653490 | 0.66 | CYP3A4 (0.41) | MEN1KMT2ACYP3A4MAPTPTGDR2 | |
| SCHEMBL31045579 | 0.66 | ALOX5AP (0.36) | — | |
| SCHEMBL27484415 | 0.65 | HPGD (0.44) | HPGDALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL31045604 | 0.65 | PDE4B (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |