Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.35 |
| ▸ | SOD1 | P00441 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654649 | 0.99 | PTGDR2 (0.37) | PTGDR2PTGDRSOD1MAPTCYP3A4 | |
| SCHEMBL2653194 | 0.83 | CYP3A4 (0.39) | PTGDR2PTGDRCYP3A4 | |
| SCHEMBL2653490 | 0.82 | CYP3A4 (0.41) | PTGDR2PTGDRMAPTCYP3A4MEN1 | |
| SCHEMBL2655032 | 0.81 | HPGD (0.43) | PTGDR2PTGDRSOD1MAPTCYP3A4 | |
| SCHEMBL2654132 | 0.80 | PTGS2 (0.41) | PTGDR2PTGDRALDH1A1MEN1KMT2A | |
| SCHEMBL2655512 | 0.71 | PTGDR2 (0.55) | PTGDR2MAPTCYP3A4MEN1KMT2A | |
| SCHEMBL4678779 | 0.69 | HSD11B1 (0.40) | HRH3ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31045579 | 0.68 | ALOX5AP (0.36) | — | |
| SCHEMBL31045604 | 0.68 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1599280 | 0.67 | SMN1; SMN2 (0.43) | CYP3A4ALDH1A1MEN1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |