Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.55 |
| ▸ | POLA1 | P09884 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653490 | 0.80 | CYP3A4 (0.41) | PTGDR2MAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL2654413 | 0.80 | PTGDR2 (0.51) | PTGDR2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2653280 | 0.78 | PTGS2 (0.44) | MEN1KMT2ACYP3A4 | |
| SCHEMBL2653194 | 0.78 | CYP3A4 (0.39) | PTGDR2CYP3A4 | |
| SCHEMBL2653394 | 0.77 | PTGDR2 (0.50) | PTGDR2OPRD1CYP3A4 | |
| SCHEMBL2652827 | 0.76 | PTGS2 (0.42) | MEN1KMT2ACYP3A4 | |
| SCHEMBL2652798 | 0.75 | ALDH1A1 (0.42) | MAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL19438820 | 0.75 | KMT2A (0.54) | POLA1KMT2ACYP3A4 | |
| SCHEMBL8524018 | 0.74 | PDE7A (0.43) | POLA1MEN1KMT2ACYP3A4 | |
| SCHEMBL2652919 | 0.73 | CNR2 (0.36) | PTGDR2NPC1RAB9AKMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |