Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653490 | 0.83 | CYP3A4 (0.41) | PTGDR2CYP3A4PTGDRMEN1KMT2A | |
| SCHEMBL2653194 | 0.81 | CYP3A4 (0.39) | PTGDR2CYP3A4PTGDR | |
| SCHEMBL2655512 | 0.80 | PTGDR2 (0.55) | PTGDR2CYP3A4NPC1RAB9AMEN1 | |
| SCHEMBL2653280 | 0.79 | PTGS2 (0.44) | CYP3A4PTGDRMEN1KMT2A | |
| SCHEMBL2652827 | 0.77 | PTGS2 (0.42) | CYP3A4PTGDRMEN1KMT2A | |
| SCHEMBL10418115 | 0.76 | AKR1C1 (0.51) | PTGDR2CYP3A4HDAC4HSD11B1MEN1 | |
| SCHEMBL2652798 | 0.76 | ALDH1A1 (0.42) | CYP3A4POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2653810 | 0.75 | PTGDR2 (0.46) | PTGDR2PTGDRPTPRBOPRL1F2RL1 | |
| SCHEMBL2793934 | 0.75 | APP (0.48) | CYP3A4HDAC4APPCYP2C9CYP2C19 | |
| SCHEMBL2652919 | 0.74 | CNR2 (0.36) | PTGDR2CYP3A4NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |