Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657137 | 0.98 | PLA2G4A (0.44) | CES1PLA2G4AFDPSALDH1A1TSHR | |
| SCHEMBL175216 | 0.87 | FDPS (0.43) | CES1PLA2G4AFDPSALDH1A1TSHR | |
| SCHEMBL7174088 | 0.86 | CES1 (0.49) | CES1PLA2G4ATBXAS1 | |
| Hydrochloric Acid SCHEMBL31146299 | 0.86 | FDPS (0.42) | CES1PLA2G4AFDPSALDH1A1TSHR | |
| SCHEMBL11156307 | 0.84 | PLA2G4A (0.48) | CES1PLA2G4ATBXAS1 | |
| SCHEMBL19929602 | 0.83 | PLA2G4A (0.43) | CES1PLA2G4AFDPSALDH1A1TSHR | |
| Urea SCHEMBL7180010 | 0.81 | PLA2G4A (0.45) | PLA2G4AFDPSALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7184826 | 0.81 | COPS5 (0.39) | CES1FDPSALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6179956 | 0.79 | SMN1; SMN2 (0.44) | CES1PLA2G4AFDPSALDH1A1SMN1; SMN2 | |
| SCHEMBL7275156 | 0.78 | FDPS (0.41) | CES1PLA2G4AFDPSALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091947-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2009-08-26 | — | — | EP | claimed |
| WO-2008079787-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2008-07-03 | — | — | WO | claimed |
| EP-2091947-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008079787-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2008-07-03 | — | — | WO | disclosed |