Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CFD | P00746 | 1/20 | 0.56 |
| ▸ | PTPRC | P08575 | 2/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.55 |
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.54 |
| ▸ | FEN1 | P39748 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26119946 | 0.89 | HPGD (0.69) | HPGDKDM4EALDH1A1SMN1; SMN2HDAC8 | |
| SCHEMBL26114243 | 0.89 | HPGD (0.73) | HPGDKDM4EALDH1A1SMN1; SMN2HDAC8 | |
| SCHEMBL1840451 | 0.87 | KDM4E (0.60) | HPGDKDM4EALDH1A1SMN1; SMN2HDAC8 | |
| SCHEMBL26568778 | 0.84 | MAPK1 (0.80) | HPGDKDM4EALDH1A1SMN1; SMN2HDAC8 | |
| SCHEMBL71847 | 0.84 | KDM4E (0.65) | HPGDKDM4EALDH1A1SMN1; SMN2HDAC8 | |
| SCHEMBL11675554 | 0.83 | PPARG (0.62) | HPGDKDM4EALDH1A1SMN1; SMN2HDAC8 | |
| Hippuric Acid SCHEMBL428479 | 0.83 | GAA (0.68) | KDM4ESMN1; SMN2HDAC8EPHX2PTPRC | |
| SCHEMBL22030672 | 0.83 | GAA (0.68) | KDM4ESMN1; SMN2HDAC8EPHX2PTPRC | |
| Hippuric Acid SCHEMBL7486 | 0.83 | GAA (0.68) | KDM4ESMN1; SMN2HDAC8EPHX2PTPRC | |
| SCHEMBL18376133 | 0.83 | CFD (0.64) | HPGDKDM4EALDH1A1SMN1; SMN2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023183405-A2 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ALEXION PHARMACEUTICALS, INC. (US) | 2023-09-28 | — | — | WO | disclosed |