Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26548758 | 0.86 | MAP4K1 (0.37) | MAPK8LMNAMAPTMEN1KMT2A | |
| SCHEMBL26536562 | 0.79 | MAP4K1 (0.32) | MAPK8LMNAMAPTMEN1KMT2A | |
| SCHEMBL1154553 | 0.79 | CYP1A2 (0.51) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4537708 | 0.77 | FDPS (0.44) | FLT3MAPK8HCAR3FDPS | |
| SCHEMBL7987681 | 0.77 | HRH3 (0.40) | FLT3MAPK8LMNA | |
| SCHEMBL16244502 | 0.77 | ROCK1 (0.40) | LMNAMAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL21017395 | 0.76 | ALDH1A1 (0.37) | FLT3MAPK8PIM1LMNAMAPT | |
| SCHEMBL15357779 | 0.75 | FLT3 (0.41) | FLT3MAPK8TRPM8MAPK10MAPK14 | |
| SCHEMBL2844731 | 0.75 | ABL1 (0.52) | FLT3MAPK8PIM1MAPTMEN1 | |
| SCHEMBL26548519 | 0.74 | CCR1 (0.52) | KCNH3MAPK10MAPK14CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |