Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29531890 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2926248 | 0.99 | ALDH1A1 (0.64) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL15800712 | 0.89 | ALDH1A1 (0.78) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL922597 | 0.86 | ALDH1A1 (0.70) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL4572914 | 0.86 | KCNJ1 (0.70) | ALDH1A1KDM4ETDP1SIGMAR1KCNJ1 | |
| SCHEMBL13398457 | 0.85 | SIGMAR1 (0.54) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL3568406 | 0.85 | ALDH1A1 (0.68) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL922442 | 0.85 | ALDH1A1 (0.68) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL5578769 | 0.84 | ALDH1A1 (0.67) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL2716970 | 0.82 | ALDH1A1 (0.73) | ALDH1A1KDM4ETDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817489-A | BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES | ISIS PHARMACEUTICALS, INC. (US) | 1998-10-06 | — | — | US | claimed |
| CN-117285485-A | Bis-sulfonamide derivative and preparation method and application thereof | 复旦大学 | 2023-12-26 | — | — | CN | disclosed |
| CN-110615774-B | Benzyl piperazine compound with anti-inflammatory activity, preparation method and medical application | 安徽中医药大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-109111415-B | Dendrobium alkaloid derivative, preparation method and medical application | 安徽中医药大学 | 2022-08-23 | — | — | CN | disclosed |
| CN-114213415-A | Macrocyclic pyrimidine derivatives | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-106164075-B | Macrocyclic pyrimidine derivatives | 詹森药业有限公司 | 2021-11-26 | — | — | CN | disclosed |
| CN-110615774-A | Benzyl piperazine compound with anti-inflammatory activity, preparation method and medical application | 安徽中医药大学 | 2019-12-27 | — | — | CN | disclosed |
| CN-106132964-B | Big ring pyridine derivate | 詹森药业有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-109111415-A | A kind of dendrobium nobile alcaloid-derivatives, preparation method and medical usage | 安徽中医药大学 | 2019-01-01 | — | — | CN | disclosed |
| US-10017509-B2 | Macrocylic pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2018-07-10 | — | — | US | disclosed |
| US-5817489-A | BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES | ISIS PHARMACEUTICALS, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5798360-A | ANTIBACTERIAL AGENTS | ISIS PHARMACEUTICALS, INC. (US) | 1998-08-25 | — | — | US | disclosed |
| US-5780241-A | ALTERING ELECTROCHEMICAL PROPERTIES BY DECYCLIZATION | ISIS PHARMACEUTICALS, INC. (US) | 1998-07-14 | — | — | US | disclosed |
| WO-1998020349-A1 | COMPLEX CHEMICAL LIBRARIES | ISIS PHARMACEUTICALS, INC. (US) | 1998-05-14 | — | — | WO | disclosed |
| US-5731438-A | BACTERICIDES; DRUGS | ISIS PHARMACEUTICALS, INC. (US) | 1998-03-24 | — | — | US | disclosed |
| WO-1998005332-A1 | NOVEL HETEROCYCLE COMPOSITIONS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-12 | — | — | WO | disclosed |
| EP-0252670-B1 | 2-SUBSTITUTED ALKOXY-3-SUBSTITUTED-PYRAZINES | TOYO JOZO KABUSHIKI KAISHA (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-5001237-A | 2-substituted alkoxy-3-substituted-pyrazines | TOYO JOZO KABUSHIKI KAISHA (JP) | 1991-03-19 | — | — | US | disclosed |
| US-4894453-A | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | TOYO JOZO KABUSHIKI KAISHA (JP) | 1990-01-16 | — | — | US | disclosed |
| EP-0252670-A2 | 2-Substituted alkoxy-3-substituted-pyrazines | TOYO JOZO KABUSHIKI KAISHA (JP) | 1988-01-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10017509-B2 | Macrocylic pyrimidine derivatives | EEF2K, VPS26B, VPS28 | ALDH1A1 4293/4885KDM4E 1710/4885TDP1 1399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.