Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | SIK1 | P57059 | 1/20 | 0.35 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659305 | 1.00 | GABRA1 (0.48) | GABRA1NPC1RAB9AFGFR1MAPT | |
| SCHEMBL2657582 | 0.88 | THRB (0.39) | GABRA1FGFR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2657860 | 0.86 | GABRA1 (0.46) | GABRA1NPC1RAB9AFGFR1MAPT | |
| SCHEMBL2656812 | 0.85 | FGFR1 (0.39) | GABRA1NPC1FGFR1MAPTALDH1A1 | |
| SCHEMBL2652796 | 0.84 | GABRA1 (0.49) | GABRA1NPC1RAB9AFGFR1MAPT | |
| SCHEMBL2651393 | 0.84 | GABRA1 (0.49) | GABRA1NPC1RAB9AFGFR1MAPT | |
| SCHEMBL2652767 | 0.84 | GABRA1 (0.49) | GABRA1NPC1RAB9AFGFR1MAPT | |
| SCHEMBL2656109 | 0.83 | FGFR1 (0.38) | FGFR1MAPTALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL2659103 | 0.82 | FGFR1 (0.43) | GABRA1FGFR1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2658314 | 0.82 | SIK1 (0.40) | FGFR1MAPTALDH1A1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055125-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | claimed |
| WO-2010055125-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | disclosed |