Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660197 | 1.00 | MAPT (0.39) | MAPTALDH1A1HSD17B10NPSR1MAPK1 | |
| SCHEMBL2659555 | 1.00 | MAPT (0.39) | MAPTALDH1A1HSD17B10NPSR1MAPK1 | |
| SCHEMBL27875747 | 0.88 | MAPT (0.33) | MAPTALDH1A1HSD17B10NPSR1MAPK1 | |
| SCHEMBL2658624 | 0.83 | MAPT (0.37) | MAPTALDH1A1HSD17B10NPSR1 | |
| SCHEMBL2659785 | 0.78 | SHBG (0.34) | MAPTALDH1A1HSD17B10NPSR1 | |
| SCHEMBL2661080 | 0.78 | EPHX1 (0.33) | MAPTALDH1A1HSD17B10 | |
| SCHEMBL2658572 | 0.78 | EPHX1 (0.33) | MAPTALDH1A1HSD17B10 | |
| SCHEMBL2659288 | 0.78 | SHBG (0.34) | MAPTALDH1A1HSD17B10NPSR1 | |
| SCHEMBL2658653 | 0.78 | SHBG (0.34) | MAPTALDH1A1HSD17B10NPSR1 | |
| SCHEMBL2658545 | 0.77 | LMNA (0.36) | MAPTNPSR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904466-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006760-A1 | DICYCLOALKYL UREA GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2007-01-18 | — | — | WO | disclosed |