Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38660994 | 0.79 | ALOX15 (0.41) | ALDH1A1LMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL1670929 | 0.79 | ALOX15 (0.41) | ALDH1A1LMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL18824676 | 0.78 | ALDH1A1 (0.40) | ALDH1A1LMNARIPK1CYP1A2CYP3A4 | |
| SCHEMBL1720706 | 0.76 | KMO (0.49) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10718871 | 0.75 | CSNK2A1 (0.36) | ALDH1A1KMT2AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL27956903 | 0.75 | KMO (0.36) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2762628 | 0.74 | KDM4E (0.40) | ALDH1A1CYP1A2MAPK1ALOX15KMT2A | |
| SCHEMBL9987095 | 0.73 | P2RX7 (0.43) | ALDH1A1LMNARIPK1HSD17B10KMT2A | |
| Lithium Ion SCHEMBL31704998 | 0.73 | CA1 (0.34) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL24921781 | 0.71 | SYK (0.35) | ALDH1A1CYP1A2CYP3A4CYP2C19MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010520-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | Pfizer Products Incorporated (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007122482-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2007-11-01 | — | — | WO | disclosed |