SCHEMBL265977

SCHEMBL265977

CCN(CC)CCNCc1cccc(C(=O)Nc2c(C)csc2C(=O)NN=Cc2ccc(Cl)c(C(F)(F)F)c2)c1

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC34A2 O95436 11/20 0.49
MAPT P10636 2/20 0.35
LMNA P02545 2/20 0.35
GAA P10253 1/20 0.35
RAB9A P51151 1/20 0.35
ADCYAP1R1 P41586 2/20 0.35
KDM4E B2RXH2 1/20 0.34
POLB P06746 1/20 0.34
ALDH1A1 P00352 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL273728 1.00 SLC34A2 (0.49) SLC34A2MAPTLMNAGAARAB9A
SCHEMBL265976 1.00 SLC34A2 (0.49) SLC34A2MAPTLMNAGAARAB9A
SCHEMBL267084 0.89 SLC34A2 (0.55) SLC34A2MAPTLMNAGAARAB9A
SCHEMBL273858 0.89 SLC34A2 (0.55) SLC34A2MAPTLMNAGAARAB9A
SCHEMBL267083 0.89 SLC34A2 (0.55) SLC34A2MAPTLMNAGAARAB9A
SCHEMBL267050 0.89 SLC34A2 (0.58) SLC34A2MAPTLMNAGAARAB9A
SCHEMBL274180 0.89 SLC34A2 (0.58) SLC34A2MAPTLMNAGAARAB9A
SCHEMBL267051 0.89 SLC34A2 (0.58) SLC34A2MAPTLMNAGAARAB9A
SCHEMBL266676 0.88 ALDH1A1 (0.39) SLC34A2MAPTLMNAGAARAB9A
SCHEMBL266675 0.88 ALDH1A1 (0.39) SLC34A2MAPTLMNAGAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885MAPT 4195/4885LMNA 2001/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885MAPT 4648/4885LMNA 1925/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.