Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 5/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | DRD3 | P35462 | 2/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660035 | 0.94 | ITGB3 (0.33) | ITGB3ITGA2BLMNATP53THRB | |
| SCHEMBL2661566 | 0.89 | ITGB3 (0.33) | ITGB3ITGA2BLMNATP53THRB | |
| SCHEMBL2660001 | 0.89 | ITGB3 (0.34) | ITGB3ITGA2BLMNATP53THRB | |
| SCHEMBL2659662 | 0.88 | ITGB3 (0.32) | ITGB3ITGA2BLMNATP53THRB | |
| SCHEMBL2661196 | 0.88 | LMNA (0.38) | LMNATP53THRBMAPT | |
| SCHEMBL2660656 | 0.88 | LMNA (0.33) | ITGB3ITGA2BLMNATP53THRB | |
| SCHEMBL2660508 | 0.87 | SYK (0.33) | ITGB3ITGA2BLMNATP53THRB | |
| SCHEMBL2659492 | 0.87 | ITGB3 (0.33) | ITGB3ITGA2BLMNATP53THRB | |
| SCHEMBL2659562 | 0.87 | DRD2 (0.33) | ITGB3ITGA2BLMNATP53THRB | |
| SCHEMBL13203967 | 0.83 | DRD3 (0.34) | ITGB3ITGA2BMAPTITGAVDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |