Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659015 | 0.92 | HDAC3 (0.32) | MAPTLMNAHDAC3HDAC1 | |
| SCHEMBL2660524 | 0.91 | RAB9A (0.35) | MAPTKDM4ENPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2661312 | 0.89 | MAPT (0.39) | MAPTKDM4ENPSR1ALDH1A1HSD17B10 | |
| SCHEMBL2659802 | 0.88 | CTSS (0.32) | MAPTKDM4ENPSR1ALDH1A1HSD17B10 | |
| SCHEMBL2661595 | 0.87 | BDKRB1 (0.32) | HDAC3HDAC1 | |
| SCHEMBL2662038 | 0.87 | LMNA (0.38) | MAPTKDM4ENPSR1ALDH1A1HSD17B10 | |
| SCHEMBL2660213 | 0.86 | MAPT (0.38) | MAPTKDM4ENPSR1ALDH1A1HSD17B10 | |
| SCHEMBL2660564 | 0.85 | KDM4E (0.37) | MAPTKDM4ENPSR1ALDH1A1HSD17B10 | |
| SCHEMBL2660563 | 0.83 | HDAC3 (0.36) | MAPTHDAC3HDAC1MAPK1 | |
| SCHEMBL2660519 | 0.81 | HDAC3 (0.35) | MAPTKDM4ELMNAHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |