Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | WNT3A | P56704 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CASR | P41180 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660075 | 0.88 | MAPT (0.36) | KDM4EMAPTALDH1A1NPSR1HSD17B10 | |
| SCHEMBL2659987 | 0.86 | LGALS8 (0.33) | KDM4EMCL1 | |
| SCHEMBL2660524 | 0.84 | RAB9A (0.35) | KDM4EMAPTALDH1A1NPSR1MCL1 | |
| SCHEMBL2661758 | 0.84 | LGALS8 (0.32) | KDM4EMAPTNPC1MCL1 | |
| SCHEMBL2659804 | 0.81 | CTSS (0.33) | CTSSCTSLCTSKKDM4EMAPT | |
| SCHEMBL2659015 | 0.81 | HDAC3 (0.32) | MAPTLMNA | |
| SCHEMBL2660508 | 0.78 | SYK (0.33) | KDM4EMAPTALDH1A1NPSR1HSD17B10 | |
| SCHEMBL2661595 | 0.78 | BDKRB1 (0.32) | — | |
| SCHEMBL2661312 | 0.77 | MAPT (0.39) | KDM4EMAPTALDH1A1NPSR1HSD17B10 | |
| SCHEMBL2668802 | 0.76 | ITGB3 (0.33) | KDM4EMAPTALDH1A1NPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074119-A1 | INDOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050821-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-02 | — | — | WO | disclosed |