Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26611525 | 1.00 | HTR2A (0.44) | HTR2AALOX5PTGS2PPARAPPARG | |
| SCHEMBL27002095 | 0.99 | HTR2A (0.46) | HTR2AALOX5PTGS2PPARAPPARG | |
| SCHEMBL27135892 | 0.99 | HTR2A (0.46) | HTR2AALOX5PTGS2PPARAPPARG | |
| SCHEMBL27002021 | 0.93 | HTR2A (0.42) | HTR2AALOX5PTGS2PPARAPPARG | |
| SCHEMBL31455991 | 0.91 | ALOX5 (0.40) | HTR2AALOX5PTGS2PPARAPPARG | |
| SCHEMBL27002114 | 0.91 | HMGCR (0.42) | HTR2AMAPTCYP3A4CYP2C19KDM4E | |
| SCHEMBL27187213 | 0.91 | HMGCR (0.42) | HTR2AMAPTCYP3A4CYP2C19KDM4E | |
| SCHEMBL29279519 | 0.88 | HTR2A (0.39) | HTR2AALOX5PTGS2PPARAPPARG | |
| SCHEMBL27002087 | 0.88 | HTR2A (0.47) | HTR2AALOX5PTGS2PPARAPPARG | |
| SCHEMBL27131447 | 0.88 | HTR2A (0.47) | HTR2AALOX5PTGS2PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250270173-A1 | PYRIDINE DERIVATIVES FOR TREATING PSYCHIATRIC DISORDERS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2025-08-28 | — | — | US | disclosed |
| WO-2025085701-A1 | PYRIDINE DERIVATIVES FOR TREATING PSYCHIATRIC DISORDERS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2025-04-24 | — | — | WO | disclosed |
| EP-4511029-A1 | PYRIDINE DERIVATIVES FOR TREATING PSYCHIATRIC DISORDERS | Gilgamesh Pharmaceuticals, Inc. (US) | 2025-02-26 | — | — | EP | disclosed |
| US-20240166618-A1 | PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME | GILGAMESH PHARMACEUTICALS, INC. (US) | 2024-05-23 | — | — | US | disclosed |
| CN-117642379-A | Phenylalkylamines and methods of making and using the same | 吉尔伽美什制药公司 | 2024-03-01 | — | — | CN | disclosed |
| EP-4305019-A1 | PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME | Gilgamesh Pharmaceuticals, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2023205116-A1 | PYRIDINE DERIVATIVES FOR TREATING PSYCHIATRIC DISORDERS | GILGAMESH PHARMACEUTICALS, INC. (US) | 2023-10-26 | — | — | WO | disclosed |
| WO-2022192781-A1 | PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME | GILGAMESH PHARMACEUTICALS, INC. (US) | 2022-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240166618-A1 | PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME | PNMT, HTR6, HTR2C | HTR2A 11/4885ALOX5 574/4885PTGS2 1481/4885 |
| US-20250270173-A1 | PYRIDINE DERIVATIVES FOR TREATING PSYCHIATRIC DISORDERS | GRIN2C, HTR1A, GRIA4 | HTR2A 40/4885ALOX5 3713/4885PTGS2 3261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.