Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 10/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.49 |
| ▸ | PLAT | P00750 | 8/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 8/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.49 |
| ▸ | F7 | P08709 | 6/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 6/20 | 0.41 |
| ▸ | F2 | P00734 | 5/20 | 0.41 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28628791 | 0.86 | PLAU (0.49) | PLAUPRSS1PLATPRSS2PRSS3 | |
| SCHEMBL6832583 | 0.82 | BCAT2 (0.50) | PLAUPRSS1PLATPRSS2PRSS3 | |
| Guanidine SCHEMBL10623936 | 0.79 | MYC (0.46) | PLAUPRSS1PLATPRSS2PRSS3 | |
| SCHEMBL26612959 | 0.77 | PLAU (0.43) | PLAUPRSS1PLATPRSS2PRSS3 | |
| SCHEMBL2154043 | 0.77 | MYC (0.61) | PLAUPRSS1PLATPRSS2PRSS3 | |
| SCHEMBL5141352 | 0.76 | PDCD1 (0.52) | MYCPDCD1CD274HNF4AFGFR1 | |
| SCHEMBL7870792 | 0.75 | MYC (0.50) | PLAUPRSS1PLATPRSS2PRSS3 | |
| SCHEMBL8532468 | 0.74 | PLAU (0.39) | PLAUPRSS1PLATPRSS2PRSS3 | |
| SCHEMBL1034554 | 0.74 | BCAT2 (0.63) | PLAUPRSS1PLATPRSS2PRSS3 | |
| SCHEMBL6830746 | 0.74 | TRPA1 (0.44) | PLAUPRSS1PLATPRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782616-B1 | ESTROGEN RECEPTOR LIGAND TREATMENT FOR NEURODEGENERATIVE DISEASES | UNIV CALIFORNIA (US) | 2023-11-01 | — | — | EP | disclosed |