SCHEMBL26627005

SCHEMBL26627005

Cc1ccc(-c2cc(C)c([Si](C)(C)C)cc2C)c(C)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
MAPT P10636 4/20 0.38
GAA P10253 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 2/20 0.37
KDM4E B2RXH2 1/20 0.37
PDE3B Q13370 1/20 0.37
PDE3A Q14432 1/20 0.37
LMNA P02545 2/20 0.36
ALPL P05186 2/20 0.36
CA9 Q16790 1/20 0.36
TP53 P04637 3/20 0.35
TDP1 Q9NUW8 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
FGFR1 P11362 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28033237 0.78 TDP1 (0.44) NPC1RAB9AMEN1KMT2ASMN1; SMN2
SCHEMBL31547677 0.78 TDP1 (0.52) NPC1RAB9AMEN1KMT2AMAPT
SCHEMBL3043421 0.78 TDP1 (0.52) NPC1RAB9AMEN1KMT2AMAPT
SCHEMBL6425318 0.75 IDO1 (0.33)
SCHEMBL20076409 0.73 LMNA (0.50) NPC1RAB9AMEN1KMT2AMAPT
SCHEMBL9463221 0.73 TDP1 (0.44) GAASMN1; SMN2ALDH1A1HPGDKDM4E
SCHEMBL29038580 0.73 MAPT (0.48) NPC1RAB9AMEN1KMT2AMAPT
SCHEMBL26013322 0.72 NPC1 (0.33) NPC1RAB9AMEN1KMT2AMAPT
SCHEMBL26014555 0.72 NPC1 (0.33) NPC1RAB9AMEN1KMT2AMAPT
SCHEMBL9742211 0.70 CYP3A4 (0.36) NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230345811-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-10-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230345811-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OPRD1, L1CAM, OPRM1 NPC1 1706/4885RAB9A 1045/4885MEN1 1446/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.