Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CHKA | P35790 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL26627009 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KDM4ERAB9ALMNAACHE | |
| Hydrochloric Acid SCHEMBL26627013 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4ERAB9ALMNAACHE | |
| Hydrochloric Acid SCHEMBL26627011 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4ERAB9ALMNAACHE | |
| Hydrochloric Acid SCHEMBL7307884 | 0.79 | ALDH1A1 (0.56) | ALDH1A1KDM4ERAB9ALMNAACHE | |
| SCHEMBL5307716 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4ERAB9ALMNAACHE | |
| Hydrochloric Acid SCHEMBL10670016 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KDM4ERAB9ALMNAACHE | |
| Hydrochloric Acid SCHEMBL5155076 | 0.73 | ALDH1A1 (0.61) | ALDH1A1KDM4ERAB9ALMNASMN1; SMN2 | |
| SCHEMBL15836459 | 0.72 | ALDH1A1 (0.49) | ALDH1A1KDM4ERAB9ALMNAACHE | |
| SCHEMBL28927098 | 0.72 | ACHE (0.51) | ALDH1A1KDM4ERAB9ALMNAACHE | |
| Hydrochloric Acid SCHEMBL19468916 | 0.71 | ALDH1A1 (0.51) | ALDH1A1KDM4ERAB9ALMNAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240279179-A1 | SYNTHESIS AND USE OF 1-BENZYL-4-METHYL-5-ALKOXY-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVE | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2024-08-22 | — | — | US | disclosed |
| CN-112645866-B | Synthesis and application of 1-benzyl-4-methyl-5-alkoxy-1, 2,3, 6-tetrahydropyridine derivative | 浙江奥翔药业股份有限公司 | 2024-03-22 | — | — | CN | disclosed |
| EP-4269391-A1 | SYNTHESIS AND USE OF 1-BENZYL-4-METHYL-5-ALKOXY-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVE | Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) | 2023-11-01 | — | — | EP | disclosed |
| CN-112645866-A | Synthesis and application of 1-benzyl-4-methyl-5-alkoxy-1, 2,3, 6-tetrahydropyridine derivative | 浙江奥翔药业股份有限公司 | 2021-04-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240279179-A1 | SYNTHESIS AND USE OF 1-BENZYL-4-METHYL-5-ALKOXY-1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVE | JAK1, JAK2, JAK3 | ACHE 4715/4885ALDH1A1 2376/4885KDM4E 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.