Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.43 |
| ▸ | JAK3 | P52333 | 5/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623067 | 1.00 | JAK1 (0.43) | JAK1JAK3JAK2TYK2CCNK | |
| SCHEMBL30622798 | 0.85 | CSNK1D (0.46) | JAK1JAK3JAK2TYK2CSNK1D | |
| SCHEMBL26645620 | 0.85 | CSNK1D (0.46) | JAK1JAK3JAK2TYK2CSNK1D | |
| SCHEMBL30622774 | 0.85 | CSNK1D (0.43) | JAK1JAK3JAK2TYK2CSNK1D | |
| SCHEMBL30622918 | 0.85 | CDK9 (0.39) | JAK1CCNKCDK12CSNK1DKIT | |
| SCHEMBL30622788 | 0.85 | JAK1 (0.43) | JAK1JAK3JAK2TYK2KIT | |
| SCHEMBL26645508 | 0.85 | CDK9 (0.39) | JAK1CCNKCDK12CSNK1DKIT | |
| SCHEMBL30622787 | 0.85 | BTK (0.40) | JAK1JAK3CCNKCDK12KIT | |
| SCHEMBL26645259 | 0.85 | JAK1 (0.43) | JAK1JAK3JAK2TYK2KIT | |
| SCHEMBL26645177 | 0.85 | BTK (0.40) | JAK1JAK3CCNKCDK12KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |