Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | MARS1 | P56192 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.36 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623037 | 0.87 | NR1H2 (0.43) | GRM5MAPTP2RY14 | |
| SCHEMBL30622875 | 0.86 | GRM5 (0.50) | GRM5NPC1MAPTRAB9ATACR3 | |
| SCHEMBL26645190 | 0.86 | GRM5 (0.50) | GRM5NPC1MAPTRAB9ATACR3 | |
| SCHEMBL26645493 | 0.80 | GRM5 (0.40) | GRM5NPC1RAB9ASMN1; SMN2TACR3 | |
| SCHEMBL26645036 | 0.77 | GRM5 (0.39) | GRM5SMOCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL26645490 | 0.77 | GRM5 (0.39) | GRM5SMOCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL30622756 | 0.75 | GRM5 (0.45) | GRM5TACR3 | |
| SCHEMBL26645645 | 0.74 | SMO (0.41) | SMOCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL25433103 | 0.71 | GRM5 (0.41) | GRM5MAPTSMN1; SMN2 | |
| SCHEMBL26645168 | 0.71 | GRM5 (0.41) | GRM5MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |