Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623059 | 1.00 | JAK1 (0.43) | JAK1JAK2MAPTBTKNR3C1 | |
| SCHEMBL30622304 | 0.88 | JAK3 (0.42) | BTKBRD4CREBBPTRPV1JAK3 | |
| SCHEMBL26644864 | 0.88 | JAK3 (0.42) | BTKBRD4CREBBPTRPV1JAK3 | |
| SCHEMBL30622881 | 0.86 | CCNT1 (0.42) | JAK1JAK2BTKJAK3PTK2 | |
| SCHEMBL26645323 | 0.86 | CCNT1 (0.42) | JAK1JAK2BTKJAK3PTK2 | |
| SCHEMBL26645714 | 0.83 | MKNK1 (0.48) | JAK1JAK2BTKMKNK1GPR119 | |
| SCHEMBL30622787 | 0.82 | BTK (0.40) | JAK1BTKJAK3MKNK1GPR119 | |
| SCHEMBL26645177 | 0.82 | BTK (0.40) | JAK1BTKJAK3MKNK1GPR119 | |
| SCHEMBL26645254 | 0.81 | MAPT (0.48) | JAK1JAK2MAPTNR3C1BRD4 | |
| SCHEMBL30622795 | 0.80 | CSNK1E (0.42) | BTKCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023213882-A1 | IRREVERSIBLE MUTEGFR INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | WO | disclosed |