Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643137 | 0.80 | ALDH1A1 (0.41) | ALDH1A1LMNARECQLRAB9AMAPT | |
| SCHEMBL29085887 | 0.76 | KDM4E (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2ACES2 | |
| SCHEMBL642860 | 0.67 | ALDH1A1 (0.59) | ALDH1A1LMNARECQLRAB9AMAPT | |
| SCHEMBL6606973 | 0.63 | ALDH1A1 (0.53) | ALDH1A1LMNARECQLRAB9AMAPT | |
| SCHEMBL2961818 | 0.62 | SLC6A3 (0.38) | ALDH1A1LMNARECQLRAB9AMAPT | |
| SCHEMBL132169 | 0.60 | ALDH1A1 (0.61) | ALDH1A1LMNARECQLMAPTNCEH1 | |
| SCHEMBL12261048 | 0.60 | CES2 (0.68) | ALDH1A1LMNAMAPTHPGDMEN1 | |
| SCHEMBL3545870 | 0.60 | ALDH1A1 (0.66) | ALDH1A1LMNARECQLMAPTNCEH1 | |
| SCHEMBL642847 | 0.60 | ALDH1A1 (0.60) | ALDH1A1LMNARAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4151206 | 0.60 | ALDH1A1 (0.43) | ALDH1A1LMNARECQLRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842713-B2 | Fused phenyl amido heterocyclic compounds | PFIZER INC (US) | 2010-11-30 | — | — | US | disclosed |
| US-20080280875-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280875-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS | GCK, GCKR, HK1 | ALDH1A1 1370/4885LMNA 2969/4885RECQL 1587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.