SCHEMBL642860

SCHEMBL642860

CN(C)C(=O)c1ccc(Br)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
HPGD P15428 1/20 0.59
CES2 O00748 1/20 0.54
CES1 P23141 1/20 0.54
LMNA P02545 3/20 0.52
RAB9A P51151 2/20 0.52
RECQL P46063 1/20 0.52
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
MAPT P10636 2/20 0.50
HTT P42858 1/20 0.49
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6606973 0.94 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2HPGDCES2CES1
SCHEMBL1004649 0.87 ALDH1A1 (0.73) ALDH1A1SMN1; SMN2HPGDLMNAMAPT
SCHEMBL4113301 0.85 MAOA (0.58) SMN1; SMN2LMNARAB9ACA1CA2
SCHEMBL25210660 0.82 CES2 (0.50) ALDH1A1SMN1; SMN2HPGDCES2CES1
SCHEMBL24669260 0.80 KDM4E (0.50) ALDH1A1HPGDCES2CES1LMNA
SCHEMBL10626283 0.80 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2HPGDLMNAMAPT
SCHEMBL22545672 0.80 SMN1; SMN2 (0.63) SMN1; SMN2MAPTHTTMEN1KMT2A
SCHEMBL1421627 0.79 MEN1 (0.56) ALDH1A1SMN1; SMN2HPGDCES2CES1
SCHEMBL12101326 0.79 HDAC4 (0.47) ALDH1A1SMN1; SMN2HPGDCES2CES1
SCHEMBL25560485 0.79 CES2 (0.46) ALDH1A1SMN1; SMN2CES2CES1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 254 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220380401-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS GALECTO BIOTECH AB (DK) 2022-12-01 US claimed
CN-115286562-A Benzoylation method of aromatic heterocyclic or aromatic amine compound containing rich electrons 青海大学 2022-11-04 CN claimed
US-11447517-B2 Galactoside inhibitor of galectins GALECTO BIOTECH AB (DK) 2022-09-20 US claimed
US-4386053-A IMPREGNATION OF SUBSTRATE WITH ORGANIC PEROXIDE, CHROMOGEN, BUFFER AND STABILIZER TERUMO CORPORATION (JP) 1983-05-31 US claimed
US-12552804-B2 Tricyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2026-02-17 US disclosed
US-20260014147-A1 STAT6 DEGRADERS GILEAD SCIENCES INC (US) 2026-01-15 US disclosed
US-20260001893-A1 SMALL MOLECULE MODULATORS OF STAT6 GILEAD SCIENCES INC (US) 2026-01-01 US disclosed
US-20250340551-A1 SMALL MOLECULE MODULATORS OF STAT6 GILEAD SCIENCES INC (US) 2025-11-06 US disclosed
US-20250325677-A1 STAT6 DEGRADERS GILEAD SCIENCES INC (US) 2025-10-23 US disclosed
US-20250320213-A1 Nitrogen-Containing Heterocyclic Compounds PFIZER INC. (US) 2025-10-16 US disclosed
US-20250320206-A1 STAT6 DEGRADERS GILEAD SCIENCES INC (US) 2025-10-16 US disclosed
US-20250320205-A1 STAT6 DEGRADERS GILEAD SCIENCES INC (US) 2025-10-16 US disclosed
EP-0284076-A1 Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds SYNTEX (U.S.A.) INC. (US) 1988-09-28 EP disclosed
EP-0275092-A1 Process for preparing (+)-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1,7-dicarboxylates SYNTEX (U.S.A.) INC. (US) 1988-07-20 EP disclosed
EP-0041711-B1 6-CHLORO- OR 6-BROMO-1,2-DIHYDRO-3H-PYRROLO(1,2-A)-PYRROLE-1-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SYNTEX (U.S.A.) INC. (US) 1985-04-17 EP disclosed
US-4410534-A 3-Substituted-5,6,7,8-tetrahydropyrrolo[1,2-a]-pyridine-and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]-azepine carboxylic acid derivatives useful as blood platelet aggregation inhibitors SYNTEX (U.S.A.) INC. (US) 1983-10-18 US disclosed
US-4386053-A IMPREGNATION OF SUBSTRATE WITH ORGANIC PEROXIDE, CHROMOGEN, BUFFER AND STABILIZER TERUMO CORPORATION (JP) 1983-05-31 US disclosed
US-4344943-A ANALGESICS, ANTIINFLAMMATORY AGENTS SYNTEX (U.S.A.) INC. (US) 1982-08-17 US disclosed
EP-0041711-A1 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo(1,2-a)-pyrrole-1-carboxylic acids and derivatives thereof, process for their production and pharmaceutical compositions containing them SYNTEX (U.S.A.) INC. (US) 1981-12-16 EP disclosed
US-4089969-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, SMOOTH MUSCLE RELAXANT SYNTEX (U.S.A.) INC. (US) 1978-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250325677-A1 STAT6 DEGRADERS STAT6, STAT5B, STAT1 ALDH1A1 959/4885SMN1; SMN2 3259/4885HPGD 1549/4885
US-20250340551-A1 SMALL MOLECULE MODULATORS OF STAT6 STAT6, STAT1, STAT5B ALDH1A1 2050/4885SMN1; SMN2 4449/4885HPGD 1739/4885
US-20250320213-A1 Nitrogen-Containing Heterocyclic Compounds HRH4, HNMT, NNT ALDH1A1 2633/4885SMN1; SMN2 1863/4885HPGD 92/4885
US-20220380401-A1 NOVEL GALACTOSIDE INHIBITOR OF GALECTINS LGALS1, LGALS3, LGALS2 ALDH1A1 1524/4885SMN1; SMN2 3065/4885HPGD 3469/4885
US-20260001893-A1 SMALL MOLECULE MODULATORS OF STAT6 STAT6, NCOR1, NCOR2 ALDH1A1 3636/4885SMN1; SMN2 4101/4885HPGD 3666/4885
US-12552804-B2 Tricyclic heterocycles as FGFR inhibitors FGFR3, FGFR1, FGFR2 ALDH1A1 478/4885SMN1; SMN2 3900/4885HPGD 2784/4885
US-20250320205-A1 STAT6 DEGRADERS STAT6, STAT1, STAT5B ALDH1A1 1225/4885SMN1; SMN2 3341/4885HPGD 1586/4885
US-20260014147-A1 STAT6 DEGRADERS STAT6, NCOR1, CBR1 ALDH1A1 1790/4885SMN1; SMN2 2651/4885HPGD 1725/4885
US-11447517-B2 Galactoside inhibitor of galectins LGALS1, LGALS3, LGALS2 ALDH1A1 1267/4885SMN1; SMN2 2962/4885HPGD 2964/4885
US-20250320206-A1 STAT6 DEGRADERS STAT6, STAT5B, STAT1 ALDH1A1 959/4885SMN1; SMN2 3259/4885HPGD 1549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.