SCHEMBL26650648

SCHEMBL26650648

O=C(Nc1cc(N2CCC(F)(F)CC2)nc2cccnc12)c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2

nearest known ligand 0.70

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30748572 1.00 KIF18A (0.70) KIF18A
SCHEMBL26650561 0.88 KIF18A (0.72) KIF18A
SCHEMBL30748583 0.88 KIF18A (0.72) KIF18A
SCHEMBL30748590 0.85 KIF18A (0.71) KIF18A
SCHEMBL31047321 0.85 KIF18A (0.66) KIF18A
SCHEMBL30748651 0.84 KIF18A (0.66) KIF18A
SCHEMBL26650437 0.84 KIF18A (0.66) KIF18A
SCHEMBL30748601 0.83 KIF18A (0.69) KIF18A
SCHEMBL31485375 0.83 KIF18A (0.75) KIF18A
SCHEMBL26650663 0.83 KIF18A (0.75) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023217230-A1 KINESIN KIF18A INHIBITOR AND USE THEREOF 上海湃隆生物科技有限公司 2023-11-16 — — WO disclosed
Send feedback