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SCHEMBL2665121

SCHEMBL2665121

CS(=O)(=O)c1cc(C(=O)/C=C(\C(=O)c2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)c2ccc3c(c2)CCCC3)ccc1OC(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ GCGR P47871 13/20 0.51
▸ GIPR P48546 8/20 0.51
▸ PPARD Q03181 2/20 0.34
▸ TRPV1 Q8NER1 2/20 0.34
▸ GLP1R P43220 2/20 0.34
▸ OPRM1 P35372 1/20 0.33
▸ OPRD1 P41143 1/20 0.33
▸ PPARG P37231 2/20 0.32
▸ PPARA Q07869 1/20 0.32
▸ MAPK14 Q16539 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2665120 0.98 GCGR (0.49) GCGRGIPRPPARDTRPV1GLP1R
SCHEMBL2664964 0.86 GCGR (0.41) GCGRGIPRPPARDTRPV1
SCHEMBL2665046 0.85 GCGR (0.47) GCGRGIPRPPARDGLP1RPPARG
SCHEMBL9071435 0.85 GCGR (0.53) GCGRGIPRTRPV1OPRM1OPRD1
SCHEMBL2665137 0.84 GCGR (0.47) GCGRGIPRTRPV1MAPK14
SCHEMBL2665135 0.82 GCGR (0.47) GCGRGIPRTRPV1OPRM1OPRD1
SCHEMBL2665091 0.81 GCGR (0.42) GCGRGIPRTRPV1GLP1ROPRM1
SCHEMBL2665086 0.80 GCGR (0.48) GCGRGIPRPPARDGLP1ROPRM1
SCHEMBL2665084 0.80 GCGR (0.42) GCGRGIPRTRPV1GLP1ROPRM1
SCHEMBL9071438 0.79 GCGR (0.45) GCGRGIPRPPARDGLP1ROPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003048109-A1 NOVEL GLUCAGON ANTAGONISTS NOVO NORDISK A/S (DK) 2003-06-12 — — WO disclosed