Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123446 | 0.83 | PDE4D (0.67) | PDE4DPDE4BKDM4EP2RY12MAPT | |
| SCHEMBL6070100 | 0.80 | KDM4E (0.62) | PDE4DPDE4BKDM4EP2RY12MAPT | |
| SCHEMBL26796556 | 0.80 | ALKBH1 (0.46) | PDE4DKDM4EMAPTALKBH1ALDH1A1 | |
| SCHEMBL26659276 | 0.80 | ALKBH1 (0.59) | PDE4DKDM4EMAPTALKBH1RAB9A | |
| SCHEMBL6069548 | 0.79 | PDE4D (1.00) | PDE4DPDE4BP2RY12MAPTALDH1A1 | |
| SCHEMBL3269737 | 0.78 | PDE4D (0.56) | PDE4DPDE4BKDM4EP2RY12MAPT | |
| SCHEMBL6070326 | 0.77 | PKM (0.62) | PDE4DPDE4BKDM4EP2RY12MAPT | |
| SCHEMBL6070059 | 0.77 | PDE4D (0.80) | PDE4DPDE4BP2RY12MAPTALDH1A1 | |
| SCHEMBL17255673 | 0.76 | PDE4B (0.74) | PDE4DPDE4BKDM4EP2RY12MAPT | |
| SCHEMBL26792019 | 0.76 | ALKBH1 (0.43) | PDE4DPDE4BKDM4EMAPTALKBH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365531-A1 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMO VIRUS | MERCK SHARP & DOHME LLC (US) | 2023-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365531-A1 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMO VIRUS | METAP1, SARS1, RTF1 | PDE4D 3582/4885PDE4B 3378/4885KDM4E 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.