Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666544 | 0.91 | RAB9A (0.35) | PORCN | |
| SCHEMBL2666710 | 0.84 | MAPK1 (0.40) | MAPK1CYP11B2MAPT | |
| SCHEMBL2643471 | 0.82 | MAPK10 (0.40) | MAPK1 | |
| SCHEMBL9071257 | 0.80 | HCRTR1 (0.37) | OPRM1OPRL1MAPK1CYP11B2 | |
| SCHEMBL2656449 | 0.78 | TSHR (0.38) | PORCNMAPT | |
| SCHEMBL2666597 | 0.76 | CACNA1H (0.38) | MAPK1MAPT | |
| SCHEMBL2666860 | 0.76 | PORCN (0.35) | PORCN | |
| SCHEMBL2666861 | 0.75 | OPRM1 (0.32) | OPRM1OPRL1PORCN | |
| SCHEMBL2643297 | 0.74 | PRKAA2 (0.40) | MAPK1 | |
| SCHEMBL2666708 | 0.73 | GCK (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053765-A2 | SUBSTITUTED CYCLOALKYLPYRROLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | disclosed |